Novel Therapies for Slowing Vision Loss Caused by Retinal Degeneration

The Role of Autophagy–Lysosomal Pathways in Photoreceptor Death in the rd10 Mouse Model of Inherited Retinal Degeneration

KA Vessey, N Hosseini Naveh, O Ehrlich, A Glover, J Lee, U Greferath, AI Jobling, EL Fletcher

2026-02-01

Inherited retinal degenerations, such as retinitis pigmentosa, are a leading cause of irreversible vision loss, yet broadly effect..

Aging of the retinal pigment epithelium

Erica L Fletcher, Jessica YW Ma, Josephine HC Wong, Una Greferath, Ophelia V Ehrlich, Andrew I Jobling, Kirstan A Vessey

2026-01-01

The retinal pigment epithelium (RPE) plays a critical role in maintaining normal vision. It is a single layer of cuboidal cells th..

The contribution of extracellular ATP to retinal function and potentiating retinal degenerations

EL Fletcher, AI Jobling, U Greferath, KA Vessey

2026-01-01

There are myriad retinal functions that are mediated by purines. P2X receptors, especially P2X7 receptors, are expressed by photor..

Systemic TRPV4 inhibition worsens retinal response to acute intraocular pressure elevation in older but not younger mice

PY Lee, U Greferath, D Zhao, JY Huang, AYM Wang, KA Vessey, V Chrysostomou, EL Fletcher, JG Crowston, BV Bui

2025-02-01

SIGNIFICANCE Previous evidence showed that transient receptor potential vanilloid 4 (TRPV4) inhibition was protective of retinal g..

The contribution of pattern recognition receptor signalling in the development of age related macular degeneration: the role of toll-like-receptors and the NLRP3-inflammasome

A Brandli, KA Vessey, EL Fletcher

2024-12-01

Age-related macular degeneration (AMD) is a leading cause of irreversible vision loss, characterised by the dysfunction and death ..

Pharmaceutical therapies targeting autophagy for the treatment of age-related macular degeneration

KA Vessey, AI Jobling, U Greferath, EL Fletcher

2024-06-01

Age-related macular degeneration (AMD) is a major cause of irreversible vision loss in the elderly. Although new therapies have re..

Aging induces cell loss and a decline in phagosome processing in the mouse retinal pigment epithelium

JYW Ma, U Greferath, JHC Wong, LJ Fothergill, AI Jobling, KA Vessey, EL Fletcher

2023-08-01

Age-related macular degeneration (AMD) is a leading cause of irreversible vision loss and dysfunction in the retinal pigment epith..

Exploring the pathogenesis of age-related macular degeneration: A review of the interplay between retinal pigment epithelium dysfunction and the innate immune system

JHC Wong, JYW Ma, AI Jobling, A Brandli, U Greferath, EL Fletcher, KA Vessey

2022-11-03

Age-related macular degeneration (AMD) is a leading cause of irreversible vision loss in the older population. Classical hallmarks..

Treatments targeting autophagy ameliorate the age-related macular degeneration phenotype in mice lacking APOE (apolipoprotein E)

KA Vessey, AI Jobling, MX Tran, AY Wang, U Greferath, EL Fletcher

2022-01-01

Age-related macular degeneration (AMD) is a leading cause of vision loss with recent evidence indicating an important role for mac..